Life is looking pretty bleak for theater director Caden Cotard (Philip Seymour Hoffman) . His wife and daughter have left him, his therapist is more interested in plugging her new book than helping him with his problems, and a strange disease is causing his body to shut down. Caden leaves his home in Schenectady, New York, and heads to New York City, where he gathers a cast of actors and tells them to live their lives within the constructs of a mock-up of the city.

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